| # | City | Population | Type |
|---|---|---|---|
| 1 | Sioux Falls | 209,289 | City |
| 2 | Rapid City | 79,894 | City |
| 3 | Aberdeen | 27,919 | City |
| 4 | Brookings | 24,555 | City |
| 5 | Watertown | 23,492 | City |
| 6 | Yankton | 15,670 | City |
| 7 | Mitchell | 15,621 | City |
| 8 | Huron | 14,515 | City |
| 9 | Box Elder | 13,887 | City |
| 10 | Spearfish | 13,803 | City |